abjection, adversity, afflict, affliction, annoyance, bale, bane, bother, botheration, calamity, casualty, chagrin, concern, cumbrance, difficulty, disaster,
disease, distress, embarrassment, fatality, fix, gloom, grid, grief, hassle, headache, heartache, inconvenience, matter, mess, misadventure, mischief, misery, misfortune, mishap, object, predicament, problem, quandary, sadness, sorrow, soulfulness, tizzy, tribulation, trouble, unhappiness, woe, worrier, worry